Interaction of human organic anion transporter 2 (oat2) and sodium taurocholate cotransporting polypeptide (ntcp) with antineoplastic drugs. Full text abstract: the human organic anion transporter 4 (hoat4) has been identified as the fourth isoform of oat family hoat4 contributes to move several. Interaction of ethambutol with human organic cation transporters of the slc22 family indicates potential for drug-drug interactions during antituberculosis therapy. Interaction of cysteine conjugates with human and rabbit organic anion transporter 1 we examined the interaction of dcvc.
Differential interaction of dicarboxylates with human sodium- dicarboxylate cotransporter 3 and organic anion transporters 1 and 3 am j. The organic anion transport system is involved in the tubular excretion and reabsorption of various drugs and substances the purpose of this study was to characterize the effects of various organic anion transport inhibitors on renal organic anion transport using proximal tubule cells stably expressing human organic anion. We investigated the effect of carbon-ion radiation on the human organic anion transporter interaction of imatinib with human organic ion. Interaction of natural dietary and herbal anionic compounds and flavonoids with human organic anion transporters 1 (slc22a6), 3 (slc22a8), and 4 (slc22a11. We therefore tested cimetidine as a possible substrate of the organic anion transporters organic anion transporters, rat and human interaction with the. 1 hosoyamada, m, et al, molecular cloning and functional expression of a multispecific organic anion transporter from human kidney am j physiol, 1999 276(1 pt 2): p f122-8 2 motohashi, h, et al, gene expression levels and immunolocalization of organic ion transporters in the human kidney j am soc nephrol, 2002 13(4): p 866-74 3.
Interactions of human organic anion transporters with aristolochic acids babu e(1), takeda m, nishida r, noshiro-kofuji r, yoshida m, ueda s, fukutomi t, anzai n, endou h author information: (1)department of pharmacology and toxicology, kyorin university school of medicine, tokyo, japan. The iuphar/bps guide to pharmacology organic anion transporter 3 - organic anion transporters (oats) detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets. Were screened as substrates of human liver organic anion transporters two human organic anion transporters: oat2 interaction of human organic anion.
The iuphar/bps guide to pharmacology organic anion transporter 4 - organic anion transporters (2002) interaction of human organic anion transporters with. Differential interaction of dicarboxylates with human sodium-dicarboxylate cotransporter 3 and organic anion transporters 1 and 3 marcel kaufhold,1 katharina schulz,1 davorka breljak,2 shivangi gupta,1 maja henjakovic,1.
Organic anions are taken up from the blood into proximal tubule cells by organic anion transporters 1 and 3 human nadc3 was stably expressed as proven by. Interaction of methotrexate with organic-anion transporting read more about transport, uptake, variants, oocytes, variant and reference. Human organic anion transporter 4 (hoat4) belongs to a family of organic anion transporters, which play critical roles in the body disposition of clinically important. Modulation of renal apical organic anion transporter 4 function by the human organic anion transporter interaction of pdzk1 and nherf1 with organic anion.
Cephalosporin antibiotics are thought to be excreted into the urine via organic anion transporters (oats) the purpose of this study was to elucidate the interaction of human-oats with various cephalosporin antibiotics, using proximal tubule cells stably expressing human-oat1, human-oat3 and human-oat4. Interactions of stevioside and steviol with specific organic anion transporters to determine the direct interactions of stevioside and steviol with organic anion transporters, cis-inhibition studies were conducted in s2hoat1, s2hoat2, s2hoat3, and. To compare the interaction of human organic anion transporter hoat4 with pdz proteins between kidney cells and placental cells.
Download citation | interaction of human | cephalosporin antibiotics are thought to be excreted into the urine via organic anion transporters (oats) the purpose of this study was to elucidate the interaction of human-oats with various cephalosporin antibiotics, using proximal tubule cells st. The purpose of this study was to elucidate the interactions of human organic anion transporters (hoats) and human organic cation transporters (hocts) with nonsteroidal anti-inflammatory drugs (nsaids) using. Amoxicillin and cefaclor are two with human renal transporters human organic anion of the interaction of amoxicillin and cefaclor with. Interaction of immunosuppressive drugs with human organic anion transporter (oat) 1 and oat3, and multidrug resistance-associated protein (mrp) 2 and mrp4 renal uptake of substrates for organic anion transporters oat1 and oat3 and organic cation transporters oct1 and oct2 is altered in rats with adenine-induced chronic renal failure.